Nitric Oxide Is a Key Determinant of Group B Streptococcus–Induced Murine Macrophage Apoptosis
نویسندگان
چکیده
منابع مشابه
Is Nitric Oxide a Hormone?
Nitric oxide (NO) is a simple ubiquitous signaling molecule and plays important roles in almost every biological system. Recent evidences suggest that NO may act as an endocrine molecule. The aim of this review is considering available literature on endocrine roles of NO and/or its metabolites, i.e. nitrite and nitrate. Existing data suggest the idea that NO is a hormone that after production i...
متن کاملGroup B streptococcus-induced nitric oxide production in murine macrophages is CR3 (CD11b/CD18) dependent.
Nitric oxide (NO) is produced by murine macrophages in response to cytokines and/or gram-negative bacterial lipopolysaccharide. NO induction by gram-positive bacteria such as group B streptococci (GBS), the major etiologic agents of neonatal pneumonia and meningitis, has received little study. GBS as well as two other gram-positive bacterial species, Staphylococcus aureus and Staphylococcus epi...
متن کاملAge-related decline in murine macrophage production of nitric oxide.
Since certain functions mediated by nitric oxide (NO) decline with age, the age dependence of NO production by macrophages from BALB/c mice was investigated. Lipopolysaccharide-, peptidoglycan-polysaccharide-, or interferon-gamma-stimulated splenic and peritoneal macrophages from young (1 month old), middle-aged (4-5 months old), and old (6-20 months old) BALB/c mice showed a progressive and ma...
متن کاملis nitric oxide a hormone?
nitric oxide (no) is a simple ubiquitous signaling molecule and plays important roles in almost every biological system. recent evidences suggest that no may act as an endocrine molecule. the aim of this review is considering available literature on endocrine roles of no and/or its metabolites, i.e. nitrite and nitrate. existing data suggest the idea that no is a hormone that after production i...
متن کاملSuperoxide formation and macrophage resistance to nitric oxide-mediated apoptosis.
RAW 264.7 macrophages, when challenged with a combination of lipopolysaccharide (10 microg/ml) and interferon-gamma (100 units/ml), respond with endogenous NO. formation, which ultimately results in apoptotic cell death. Apoptosis is detected morphologically by chromatin condensation. Concomitantly we noticed the accumulation of the tumor suppressor protein p53. NO.-derived apoptosis was blocke...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2005
ISSN: 0022-1899,1537-6613
DOI: 10.1086/429693